Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TP2206 |
[Leu31,Pro34]-Neuropeptide Y (porcine)
LEU 31, PRO34]-神经肽Y(猪) |
Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
[Leu31,Pro34]- Neuropeptide Y (porcine) 是神经肽 Y (NPY) 的一种类似物,是对NPY Y1受体有选择性的激动作用。它表现出抗焦虑作用。 | |||
T23094 |
NTNCB hydrochloride
|
Others; Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience; Others |
NTNCB hydrochloride 是一种神经肽 Y Y5 受体的拮抗剂。 | |||
TQ0286 |
MK-0557
|
Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
MK-0557 是神经肽 Y5 受体的选择性口服拮抗剂,Ki 值为1.6 nM。 | |||
T8963 |
CYM2503
|
Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
CYM2503 是 GAL2 受体的正变构调节剂 (PAM),可在体外增强甘丙肽诱导的 IP1 产生。它对受体的正构甘丙肽结合位点没有亲和力(通过其无法置换碘化甘丙肽或自行诱导 IP1 积累来衡量)。 | |||
T17222 |
Velneperit
韦利贝特,S2367 |
Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
Velneperit (S2367) 是一种有效且选择性的神经肽 Y (NPY) Y5 受体,有用于治疗肥胖症的研究潜力。 | |||
T10539 |
BIBO3304 TFA
|
Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
BIBO3304 TFA 是一种可口服的、选择性的神经肽 Y(NPY) Y1受体高效拮抗剂,对人和大鼠 Y1 受体均具有高亲和力,IC50分别为 0.38 和 0.72 nM。 | |||
T5587 |
CGP71683 hydrochloride
CGP71683A,盐酸CGP71683 |
Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
CGP71683 hydrochloride (CGP71683A) 是竞争性的神经肽受体拮抗剂,Ki 值为 1.3 nM。 | |||
T1997 |
JNJ-31020028
JNJ 31020028 |
Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
JNJ-31020028是神经肽Y2受体选择性可脑渗透抑制剂,对人Y2和鼠源Y2受体pIC50值分别为8.07和8.22,其神经肽 Y2 受体的选择性比人 Y1/Y4/Y5 受体高 100 倍。 | |||
TP1380 |
Galanin (1-16), mouse, porcine, rat
|
Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
Galanin (1-16), mouse, porcine, rat 是一种有效的甘丙肽受体激动剂,Kd 为 3 nM。 | |||
T5455 |
HT-2157
SNAP37889,SNAP-37889 |
Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
HT-2157 (SNAP-37889) 是一种高亲和力、选择性和竞争性的甘丙肽 3 受体 (Gal3) 拮抗剂。 | |||
TP1059 |
Peptide YY (PYY) (3-36), human
Peptide YY (3-36) |
Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
Peptide YY (PYY) (3-36), human (Peptide YY (3-36)) 是一种肠胃激素肽,可以激动Y2受体,具有降低食欲的功效。 | |||
T74350 |
Neuropeptide Y Y1 receptor antagonist 1
|
||
Neuropeptide Y Y1 receptor antagonist 1 (化合物 39),一种荧光探针,是神经肽 Y Y1受体 (Y1R) 的拮抗剂,Ki 值为 0.19 nM。储存方式:避光。 | |||
T8456 |
GALNON
|
Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
Galnon 是一种甘丙肽受体激动剂,可改善内在的皮质骨组织特性。 | |||
T12895 |
SHA 68
|
Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
SHA 68 是一种有效且选择性的神经肽 S 受体 (NPSR) 非肽拮抗剂,对 NPSR Asn107和 NPSR Ile107的IC50分别为 22.0 和 23.8 nM,具有有限的血脑屏障渗透能力和用于神经痛的活性。 | |||
T74654 | Neuropeptide Y5 receptor ligand-1 | ||
Neuropeptide Y5 receptor ligand-1 (compound 54),一种咔唑衍生物,作为高效的神经肽 Y5 (NPY-5) 受体拮抗剂。 | |||
TP1984L |
[D-Trp34]-Neuropeptide Y Acetate
[D-Trp34]-Neuropeptide Y Acetate (153549-84-9 Free base) |
Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
[D-Trp34]-Neuropeptide Y Acetate 是有效的、选择性的神经肽 Y (NPY) Y5 受体激动剂,在 NPY Y1,Y2,Y4 和 y6 受体上的效力较低。[D-Trp34]-Neuropeptide Y Acetate 可以显著增加大鼠的食物摄入量。 | |||
T23087 |
NPY 5RA972
|
Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
NPY 5RA972 是一种神经肽 Y Y5 受体拮抗剂 | |||
T21611L |
BWX 46 Acetate
BWX 46 Acetate(172997-92-1 Free base) |
Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
BWX 46 Acetate 是一种有效的、高度选择性的神经肽 Y (NPY) 受体激动剂,IC50 为 0.5 nM。 | |||
T23349 |
SF 11
|
Others | Others |
SF 11是一种有效的脑渗透神经肽 Y Y2 受体拮抗剂 (IC50=199 nM)。具有抗抑郁药样活性。 | |||
T71749 |
SF-22
|
Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
SF-22 是一种可透过血脑屏障的神经肽 Y 受体(Y2R) 拮抗剂,具有潜在抗炎活性,可用于研究神经系统紊乱带来的疾病。 | |||
TP1137L |
Pancreatic Polypeptide (human) acetate
|
Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
Pancreatic Polypeptide (human) acetate 是一种 C 末端酰胺化的 36 个氨基酸肽,可作为神经肽 Y (NPY) Y4/Y5 受体激动剂。 | |||
T15679 |
L 152804
|
Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
L 152804 是神经肽 Y Y5 受体的特异性拮抗剂,可调节食物摄入和能量消耗,从而导致饮食诱导的肥胖小鼠体重减轻。 | |||
T26801 |
BIBP3226
BIBP 3226,BIBP-3226 |
||
BIBP3226 is a potent and selective antagonist for the Neuropeptide Y receptor Y1 and the neuropeptide FF receptor. | |||
T22935 |
LU AA33810
|
Others | Others |
neuropeptide Y (NPY) Y5 receptor antagonist | |||
TP1081 |
Neuropeptide Y (13-36), amide, human
Neuropeptide Y (13-36), human |
||
Neuropeptide Y (13-36), amide, human is a neuropeptide Y receptor agonist. | |||
T36445 |
Neuropeptide Y (3-36) (human, rat)
|
||
Neuropeptide Y (3-36) (human, rat) is a metabolite of neuropeptide Y (NPY) generated by dipeptidyl peptidase-4 (DPP4). Known as a selective Y2 receptor agonist, Neuropeptide Y (3-36) (human, rat) effectively reduces the release of norepinephrine via the Y2 receptor[1][2]. | |||
T23287 |
S 25585
|
Others | Others |
neuropeptide Y (NPY) Y5 receptor antagonist | |||
T36447 |
Neuropeptide Y 13-36 (porcine)
|
||
Neuropeptide Y 13-36 (porcine) 是选择性的神经肽 Y2 受体激动剂。 | |||
T10540 |
BIBP3226 TFA
|
Others | Others |
BIBP3226 TFA is an effective and selective antagonist of neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor (Kis: 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF). | |||
T26008 |
PYX 2
PYX2,PYX-2 |
||
PYX 2 is used as a neuropeptide Y receptor antagonist. | |||
T27345 |
FMS586
FMS-586,FMS 586 |
||
FMS586 is a selective antagonist of neuropeptide Y Y5 receptor with oral activity. | |||
T10921 |
CYM 9484
|
Others | Others |
CYM 9484 is a selective and potent neuropeptide Y (NPY) Y2 receptor antagonist with IC50 value of 19 nM. | |||
T14572 |
BIIE-0246
AR-H 053591 |
Others | Others |
BIIE-0246 is a potent and highly selective non-peptide neuropeptide Y (NPY) Y2 receptor antagonist. With an IC50 of 15 nM. | |||
T76355 |
Neuropeptide Y (3-36) (porcine)
|
||
Neuropeptide Y (3-36) (porcine) 是一种针对 Y2 亚型的 NPY 受体的激动剂,同时也通过一种尚未明确的受体来调控大鼠的摄食行为。 | |||
T75911 |
[D-Trp34]-Neuropeptide Y TFA
|
||
[D-Trp34]-Neuropeptide Y TFA,一种高效且选择性的神经肽Y (NPY) Y5受体激动剂,其在NPY Y1、Y2、Y4及Y6受体上的活性显著低于Y5受体。该化合物能显著提高大鼠的食物摄入量。 | |||
T37528 |
tBPC
|
||
Positive allosteric modulator of neuropeptide Y receptor 4 (Y4R). Potentiates Y4R response to pancreatic polypeptide (PP), neuropeptide Y (NPY) and peptide YY (PYY) (EC50 values are 0.03, 0.4 and 0.5 nM respectively). Shows selectivity for Y4R over Y1R, Y2R and Y5R. Schubert et al (2017) Identification and characterization of the first selective Y4 receptor positive allosteric modulator. J.Med.Chem. 60 7605 PMID:28795803 | |||
T10514 |
FR252384
|
Others | Others |
FR252384 is an antagonist of the neuropeptide Y-Y5 receptor (IC50: 2.3 nM). | |||
T75912 |
[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA
|
||
[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA 是一种针对神经肽 YY1受体的特定激动剂,并亦能够激活Y4和Y5受体。该化合物能提高麻醉大鼠的血压并增加食物摄入。 | |||
T41188 |
BIBP 3226 trifluoroacetate
|
||
BIBP 3226 trifluoroacetate is a mixed non-peptide neuropeptide Y Y1(NPY Y1) and neuropeptide FF (NPFF) receptor antagonist (Kivalues are 1.1, 79, 108, > 1000, > 1000 and >1000 for rNPY Y1, hNPFF2, rNPFF, rNPY Y2, rNPY Y4and rNPY Y5respectively). Produces an anxiogenic-like effect in rats following i.c.v. administration. | |||
T76357 |
Neuropeptide Y (18-36) (porcine)
|
||
Neuropeptide Y (18-36) (porcine) 是一种与Neuropeptide Y(NPY)心脏受体进行竞争性拮抗的化合物。该化合物通过浓度依赖的方式,抑制I-NPY与心室膜的结合,具有IC50值158 nM和Ki值140 nM。Neuropeptide Y (18-36) (porcine) 主要用于充血性心力衰竭的研究。 | |||
T69621 |
BIIE-0246 HCl
|
||
BIIE-0246 is a potent, selective and competitive non-peptide antagonist for the neuropeptide Y Y2 receptor. BIIE-0246 displays > 650-fold selectivity over Y1, Y4 and Y5 receptors. | |||
T36481 | BIIE 0246 hydrochloride | ||
Potent, selective and competitive nonpeptide antagonist for the neuropeptide Y Y2 receptor (IC50 = 15 nM). Displays > 650-fold selectivity for NPY Y2 over Y1, Y4 and Y5 receptors. Active in vivo. | |||
T22608 |
BMS 193885
BMS193885 |
Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
BMS 193885 是一种选择性和竞争性神经肽 Y(1) 受体拮抗剂,亲和力为 3.3 nM。 | |||
TP1985 |
[Leu31,Pro34]-Neuropeptide Y(human,rat)
[Leu31,Pro34]-Neuropeptide Y (human, rat) |
||
High affinity neuropeptide Y Y1 receptor agonist (Ki = 0.39 nM). Also shows affinity for Y4 and Y5 receptors. | |||
T76423 |
Neuropeptide AF (cattle)
|
||
Neuropeptide AF (cattle)是一种RFamide家族的酰胺化十八肽,主要作用于Mas相关基因受体A4 (MrgprA4) (Mas-related G-protein-coupled Receptor (MRGPR))和MrgprC11,其EC50分别约为60 nM和300 nM。此外,该化合物还能激活G蛋白偶联受体NPFF1 (Neuropeptide Y Receptor) 和NPFF2,EC50范围分别为25-325 nM和1-5 nM。Neuropeptide AF (cattle)具有显著的抗阿片及疼痛调节功能。 | |||
T75730 |
[D-Arg25]-Neuropeptide Y (human)
|
||
[D-Arg25]-Neuropeptide Y (human) ([D-Arg25] NPY) 是Y1受体的选择性激动剂。与阿尔茨海默病相关,该化合物能够保护老鼠皮质神经元免受淀粉样蛋白毒性的损害。 | |||
T12623 | (R)-JNJ-31020028 | Others | Others |
(R)-JNJ-31020028 is a high affinity, selective brain penetrant antagonist of neuropeptide Y Y2 receptor(pIC50 values of 8.07, 8.22 and 8.21 for human, rat, and mouse Y2 receptor, respectively). | |||
T75910 |
GR231118 TFA
|
||
GR231118是神经肽Y的C末端类似物,作为人神经肽YY受体的高竞争性和相对选择性的拮抗剂(pKi=10.4),并对人类神经肽Y4受体显示出拮抗效果(pEC50=8.6;pKi=9.6),同时是对人及大鼠神经肽YY2与Y5受体的弱激动剂。此外,GR231118对小鼠神经肽YY6受体具有较高亲和力(pKi=8.8)。 | |||
T74459 | Y1R probe-1 | ||
Y1R probe-1 (Compound 39) 是一种针对神经肽Y Y1受体的高亲和力荧光探针,具有潜在应用于癌症疾病研究。 | |||
TP2022 |
GR231118
GR 231118 |
||
Potent neuropeptide Y (NPY) Y1 receptor antagonist (pA2 = 10 and 10.5 at rY1 and hY1, receptors respectively). Also a potent and selective NPY Y4 receptor agonist (pEC50 values are 6.0, 8.6 and 6.1 for rY2, hY4 and rY5 receptors respectively). Suppresses |